CONSIDERATIONS TO KNOW ABOUT PKRRATING

The activated enzyme then phosphorylates its main substrate, the translational initiation component eIF2α. The ensuing translational arrest blocks viral replication. PKR belongs to the conserved relatives of four protein kinases (PKR, PERK, GCN2, HRI) that every one phosphorylate eIF2α in response to various stimuli12, triggering the built-in wor